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dc.contributor.authorMartinez Calixto, Luis Edmundo
dc.date.accessioned2016-04-05T16:17:35Z
dc.date.available2016-04-05T16:17:35Z
dc.date.issued2006
dc.identifier.other304938863
dc.identifier.urihttp://hdl.handle.net/10477/49381
dc.description.abstractAmeloblastomas are odontogenic tumors that sometimes show microscopic features similar manifested by basal cell carcinomas (BCCs). The current literature indicates that anti-cytokeratin reacts in ameloblastomas, but not in BCCs, while Ber-EP4 shows opposite findings. Specific aims . To evaluate the ability of the monoclonal antibodies AE1/AE3 (anti-cytokeratin) and Ber-EP4 (anti-34/39 kD epithelial antigen) to immunohistochemically differentiate BCCs from intraosseous and peripheral ameloblastomas. Materials and methods . 10 peripheral, 11 intraosseous ameloblastomas and 10 BCCs were examined using Ber-EP4 and AE1/AE3 antibodies. Results . AE1/AE3 expression was observed in 90% of cases of BCCs and intraosseous ameloblastomas. Ber-EP4 antigens expression was seen in all cases of BCCs, 30% of intraosseous ameloblastomas and 40% of peripheral ameloblastomas. Conclusions . Our study revealed a heretofore, unrecognized expression of the Ber-EP4 antigen in some intraosseous and peripheral ameloblastomas. Our study indicates that the AE1/AE3 and Ber-EP4 probes are not able to immunohistochemically separate ameloblastomas from BCCs.
dc.languageEnglish
dc.sourceDissertations & Theses @ SUNY Buffalo,ProQuest Dissertations & Theses Global
dc.subjectHealth and environmental sciences
dc.titleIn situ expression of cytokeratins and Ber-EP4 antigen in ameloblastomas and basal cell carcinomas
dc.typeDissertation/Thesis


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