Oxidative stress in the postprandial period and the effect of variations in postprandial glycemia
de Vries, Nicholas Anthony
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There is increasing evidence that metabolic events in the postprandial state are important contributing factors to the development of atherosclerosis. The oxidative modification of lipids is central to the process of atherosclerosis and the pathogenesis of cardiovascular disease (CVD). Few studies have been conducted characterizing biomarkers of oxidative stress in the postprandial period and no non-diabetes studies have examined the possible modulating influence of glycemia. The objective of this study was to characterize the levels of selected biomarkers of oxidative stress in the postprandial period and to test the hypothesis that elevated postprandial glycemia following a breakfast and lunch meal will cause increased oxidative stress in comparison to meals that elicit lower postprandial glycemia. The results of this study are important for determining if variations in the glycemic index (GI) of the diet affect postprandial oxidative stress and may have important implications for future dietary recommendations for disease prevention.