The installation of a pyrrolidine group to a phenolic ring-one of the key steps to the total synthesis of strychnopentamine and isostrychnopentamine
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The increase of multi-drug resistance of P. falciparum, the major cause of malaria, has been threatening the world public health especially developing countries. Thus, new development of drugs to offer as alternative treatment options is necessary to continue to fight malaria. Strychnopentamine (SP) and its epimer- Isostrychopentamine (ISP) are naturally occurring lead compounds that have shown promising activity in vitro and in vivo against the parasite. However, the scarcity of the compounds prevents many studies that could be done to improve the efficiency and the cost of anti-malaria drugs. This thesis is going to address one of the key steps to the synthesis of SP and ISP – the installation of pyrrolidine ring regioselective and enantioselective to the phenolic ring.