Answering burning questions: Analysis and quantification of halogenated flame retardants and their metabolites in environmental and biological matrices
Mackintosh, Susan A.
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Polybrominated diphenyl ethers (PBDEs) are used as additive flame retardants in a number of polymers and resins found in consumer products. PBDEs have become classified as persistent organic pollutants (POPs) due to widespread use, ubiquitous environmental distribution, bioaccumulation potential, and toxicity. To evaluate the occurrence and fate of PBDEs in complex matrices it is imperative to utilize sample preparation procedures and modern analytical instrumentation that can provide accurate, reproducible, and sensitive detection. The overall goal of this work was to develop analytical strategies for the analysis of PBDEs through optimization of sample preparation and detection by gas chromatography- tandem mass spectrometry (GC-MS/MS). Developed methods were applied to assess occurrence and fate in environmental and biological matrices.