Development and Characterization of Neurodegenerative Animal Models in Mice
Curl, Ryan Andrew
MetadataShow full item record
The characterization of animal models of neurological damage is a complex but effective way to shed light on the cause of the damage and of the potential benefit of proposed therapies. In the present study we characterized two animal models, one of Parkinson's disease, the other of stroke/traumatic brain injury. The Parkinson's animal model was developed using both genetic mutation [FGFR1 (TK-)] and toxic insult via injections of Paraquat and Maneb. We characterized these animals by assessing the locomotor, olfactory, neurochemical and neuroanatomical deficits and/or changes that occurred in these animals throughout a regimen of Paraquat and Maneb injections. These animals developed a locomotor deficit and suggest an irregular olfactory ability. The male animals displayed a decrease in dopamine terminals and dopaminergic related metabolites. The stroke/traumatic brain injury animal model was established using surgical induction of brain damage. The Pial Vessel Disruption (PVD) surgery involves the removal of an area of vasculature inducing stroke in the underlying cortical tissue. These animals display a severe unilateral locomotor deficit and neuroanatomical changes in the area of the damaged cortex. We treated these animals with an α7 neuronal nicotinic receptor (NNR) agonist, TC-7020, in order to assess its therapeutic benefit post stroke/traumatic brain injury. The animals' locomotor deficit recovered at an accelerated rate in the animals that were treated with TC-7020. The neuroanatomical effects of TC-7020 on the post PVD surgery animals remain unclear and will require further investigation.