[I] Advancing the Utility of Ene-Yne Metathesis and Applications of 1,3-Dienes. [II] Synthesis of Macrocyclic Ligands for Catalysis Applications
Clark, Joseph Raymond
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The ene-yne metathesis method has been improved to accommodate a wide variety of alkene and alkyne substrates. Additionally, reactants can be used in a 1:1 stoichiometry. Access to beta-unsubstituted anti-allylic alcohols is now possible. This has allowed for geminally disubstituted alkenes to be reactive in ene-yne metathesis. The 1,3 diene products from ene-yne metathesis can be isomerized to the corresponding 1,5 hydride shift product using a new ruthenium hydride dienyl isomerization protocol. Lastly, a new macrocyclic ligand has been developed in an effort to improve metathesis efficiency through catalyst development.