Elucidating Focal Adhesion Kinase Substrate and Function
van Bruggen, David
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PTK2 or Focal Adhesion Kinase (FAK) is an important protein tyrosine kinase regulating cell motility and migration. FAK overexpression is implicated in many cancers, and FAK signaling can provide cells with changes in morphology associated with an increased invasiveness. FAK is an important player in cell motility and adhesion and signaling, and is conserved across species. Here we show that FAK can phosphorylate Peroxiredoxin 1 (Prdx1), a H2O2 scavenging protein implicated in ROS regulation in the cell. We show that FAK can affect the oligomerization of endogenous PRDX1 in HEK293T cells. Moreover Prdx1 mutants for the FAK specific site activate FAK in a different manner.