Alcohol consumption and the development of Renal Cell Carcinoma
MetadataShow full item record
Objective : The purpose of this study is to examine the association between alcohol consumption and the risk of Renal Cell Carcinoma (RCC), and potential modifying effect from physical activity, BMI, diabetes and smoking on the development of RCC. Methods : Using data collected from the Data Based Bio Repository (DBBR) by Roswell Park Cancer Institute, a 1:2 case-control study was conducted with 202 RCC cases and 404 healthy controls. An additional 1221 RCC cases and 1105 controls provided by Mayo Clinic, were analyzed as a validation study. Unconditional logistic regression was used to calculate odds ratios for crude and adjusted models, after controlling for potential confounders. Results : A U-shaped dose-response relationship was observed between overall alcohol consumption and RCC. Compared to the lowest quartile of daily ethanol consumption, consumers drinking 1.4-10.5 grams of ethanol per day, equivalent to one standard drink, had an OR of 0.57 (95% CI: 0.34-0.93). The result was validated by Mayo Clinic data with an OR of 0.50, 95% CI: 0.40-0.62. Weekly consumption of a serving of beer (OR=0.44), red (OR=0.55) or white wine (OR=0.41) appeared to provide a stronger protective effect as compared to liquor (OR=0.67, 95%CI: 0.39-1.12). The study also observed a significant interaction between alcohol consumption and physical activity with RCC. We observed over 3-fold increased risk in subjects with low consumption levels and not physically active as compared to those with high consumption level and being physically active. Conclusion : Daily consumption of a standard alcoholic beverage appeared to provide the most beneficial effect. Physical activity also appeared to modify the protective effect of alcohol consumption on RCC development.