Light triggered cargo release from porphyrin-phospholipid and metallo-porphyrin-phospholipid doped liposomes
Wang, Sophie Linyi
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The primary research aim was to investigate the feasibility of utilizing metallo-porphyrin doped liposomes as general light triggered delivery mechanisms for cargo molecules such as the anti-cancer drug mitoxantrone (MTX) or near infrared heptamethine dyes. A secondary question was: does encapsulation in metallo-porphyrin-doped liposomes increase the therapeutic index, blood circulation times, and site specificity. Compared to DOX, MTX showed better pH gradient based loading characteristics in metallo-porphyrin doped liposomes. However, the triggered release trends for MTX loaded liposomes were unsatisfactory in terms of speed and peak release in comparison to DOX loaded liposomes. Additionally, the in vivo pilot study showed that therapeutic index results did not improve as much as desired. NIR dyes were not successfully loaded with pH gradient methods and showed fluorescent bleaching in response to laser triggered release, rendering release assessments impractical. These results showed that further development is necessary for metallo-porphyrin doped liposomes to become general delivery mechanisms.