Copper-Catalyzed Intramolecular Carboetherification and Carboamination Using Alkynes to Form Fused Ring Tetrahydrofurans and Pyrrolidines
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Fused ring tetrahydrofurans and pyrrolidines are common functional motifs in many biologically active and industrially useful compounds. Carboetherification and carboamination are becoming increasingly popular as methods to form these compounds. The research in this document further expands upon the use of copper (II)-catalyzed chemistry to form these products enantioselectively. Previously, this reaction has been observed using aryl rings and alkenes to accept the radical formed in the reaction. Recent work has shown that with slight modification to the reaction conditions, alkynes can accept the radical as well. These chiral products formed can be useful synthetic building blocks for more complex targets.