Integrative genomic approaches to elucidate the role of NCOR2 in prostate cancer progression
Llimos Aubach, Gerard
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Prostate cancer depends on androgens to growth, so a standard procedure for advanced or metastatic cancer is castration or androgen deprivation therapy. However, most of the patients undergoing this treatment suffer recurrence and the cancer becomes resistant to it. In this project we want to unravel the role of the nuclear receptor co-repressor NCOR2 driving this resistance. We have analysed its cistrome in normal C4-2 cells and the transcriptome and methylome of the NCOR2 knockdown to see the effect of NCOR2 downregulation. Firstly, we have demonstrated the important role of this repressor in the androgen receptor signaling pathway. Secondly, we have shown that the knockdown has a dual effect in gene expression, 50-50 up and downregulated genes, but strikingly it provokes global hypermethylation. In conclusion, more analyses remain to be performed in order to affirm its importance in prostate cancer progression.