Enabling high-speed wide-field dynamic imaging in multi-focal photoacoustic computed microscopy
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Photoacoustic-computed microscopy (PACM) is an emerging technology that employs thousands of optical foci to provide wide-field high-resolution images of tissue optical absorption. A major limitation of PACM is the slow imaging speed, limiting its usage in dynamic imaging. In this study, the speed was improved through a two-step approach. First, compressed sensing with partially known support was employed to reduce the transducer element number, which subsequently improved the imaging speed at each optical scanning step. Second, the high speed low resolution image acquired without microlens array was used to inform dynamic changes in the high resolution PACM image. Combining both approaches, high-resolution dynamic imaging over a wide field was achieved.