The Acute Effects of Agaricus Bisporus on Modulating Postprandial Glycemic Responses Following an Oral Glucose Tolerance Test in a Healthy Population Across the Lifecycle
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OBJECTIVE: To determine the effect of Agaricus Bisporus (Portobello mushrooms) when added to a standard glucose drink in modulating postprandial glycemic responses during an Oral Glucose Tolerance Test (OGTT) in a healthy population. RESEARCH DESIGN AND METHODS: A combined total of 37 healthy males (n=13) and females (n=24) (age, 35.0±15.2, range 19-68) participated in the study. Participants completed two OGTTs with unique drinks over a one-week period. The OGTTs were evaluated in response to a 75g Glucose Drink (G) and a 75g Glucose Drink with 9.5g mushroom powder (MG). A younger subset of 21 healthy males (n=10) and females (n=11) (age, 23.2±2.7, range 19-27) completed one additional OGTT within two days of second laboratory visit. The third OGTT consisted of an equivalent fluid volume of water with 9.5 g mushroom powder and 0.5 g Stevia® (M). Blood samples were collected and analyzed for glucose concentrations at fasting and every 30 minutes after for a total of 120 minutes during each of the OGTTs. RESULTS: Females in the combined group showed an elevation in glucose at 60 minutes with the MG drink when compared to the G drink (p=0.005). Females in the combined group showed slower glucose clearance with the MG drink than with the G drink. The younger subset showed an elevation of glucose at 60 minutes with the MG drink when compared to the G drink (p=0.036). When separated by gender these treatment effects were only experienced by females of the younger subset (p=0.023). Females of the younger subset had higher levels of insulin when compared with males for the G drink at 60, 90, and 120 minutes (p=0.028, p=0.009, p=0.006) and the MG drink at 120 minutes (p=0.005). CONCLUSIONS: The consumption of Portobello mushrooms with an oral glucose load appears to cause an improvement in glucose tolerance in older males. This effect was not seen in a younger population or in an older female population.