Copper-Catalyzed Three Component Intermolecular Carboamination of Alkenes Utilizing Potassium Alkyltrifluoroborate Salts
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Metal catalyzed alkene difunctionalizations are highly useful transformations in synthetic chemistry. However, constructing carbon-carbon and carbon-nitrogen bonds in a single step still proves to be a challenging problem for these reactions. Many current carboamination reactions require a tethered amine to create the C-N bond intramolecularly, which limits their scope. Developing an efficient intermolecular carboamination reaction would be highly beneficial for the synthetic community. Here we describe a copper-catalyzed intermolecular carboamination using alkyl trifluoroborates as carbon radical sources.