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Effects of the TAAR1 agonist RO5263397 on Ethanol-induced Behavioral Sensitization
(State University of New York at Buffalo, 2018)
Trace amine-associate receptor 1 (TAAR1), was recognized as a promising target for treating drug addictions and multiple neuropsychiatric disorders, due to its function in modulating dopaminergic systems in the central ...
Amylin receptor expression in the mesocorticolimbic system
(State University of New York at Buffalo, 2018)
Despite the fact that obesity is prevalent in modern society and is a risk factor for many life-threatening conditions, effective non-invasive treatments remain limited. Amylin is a pancreatic and brain-derived peptide ...
Investigating the phenotype of amylin receptor-expressing cells in the ventral tegmental area
(State University of New York at Buffalo, 2019)
The role of amylin in regulating energy balance through its ability to suppress food intake by increasing satiation makes it a promising therapeutic method for obesity. Calcitonin receptor (CTR) is the core component of ...
The effects of immune factor, TNFα, on human fetal neural development and schizophrenia in a cerebral organoid model
(State University of New York at Buffalo, 2019)
Schizophrenia (SZ) is a psychiatric disease, which affects approximately one percent of the global population. Schizophrenia is a neurodevelopmental disorder, which affects in utero brain development within the first ...
Characterization of novel alpha2/alpha3 subtype-selective GABAA receptor positive allosteric modulators
(State University of New York at Buffalo, 2019)
Millions of individuals endure persistent pain. In the United States alone, about 30% of the population is estimated to suffer from chronic pain. In addition to the physical and emotional burden that chronic pain imparts, ...
Investigating feasibility of repetitive transcranial magnetic stimulation targeting upper limb spasticity- a case study
(State University of New York at Buffalo, 2019)
Spasticity is one of the major disability that affects an individual and his caregivers’ lives in many ways. Spasticity is usually caused due to stroke, traumatic brain injury, multiple sclerosis to name a few. It occurs ...
Opiate-Induced Plasticity in the Mesolimbic Dopamine System
(State University of New York at Buffalo, 2019)
Substance use disorder is a chronic, relapsing disease that results from cellular maladaptations within discrete regions of the mesolimbic dopamine system, or the ‘reward pathway.’ Two critical regions that are known to ...
Voltage-Gated Calcium Channels Function in Reactive Astrocytes
(State University of New York at Buffalo, 2019)
Astrocytes exhibit excitability in the form of intracellular Ca++ oscillations which are critical for the regulation of many cellular events (Cornell Bell et al., 1990). We previously reported that voltage-gated Ca++ ...
Integrating Network Science and Computational Topology with Applications in Neuroscience Data Analytics
(State University of New York at Buffalo, 2018)
Real world systems are complex, dynamic and exist across multiple scales. Recent revolutions in data collection and storage have provided researchers with unprecedented access to information about these systems in greater ...
Task Relevant Source Based Brain Computer Interface: Exploration of Independent Component Analysis Based Spatial Filtering with Reliability
(State University of New York at Buffalo, 2018)
Brain-computer interface (BCI) for visuomotor tasks requires identification of task-specific patterns of brain activity. During the visuomotor task, the subject encodes the visual information for a decision and then makes ...