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Effects of the TAAR1 agonist RO5263397 on Ethanol-induced Behavioral Sensitization
(State University of New York at Buffalo, 2018)
Trace amine-associate receptor 1 (TAAR1), was recognized as a promising target for treating drug addictions and multiple neuropsychiatric disorders, due to its function in modulating dopaminergic systems in the central ...
Amylin receptor expression in the mesocorticolimbic system
(State University of New York at Buffalo, 2018)
Despite the fact that obesity is prevalent in modern society and is a risk factor for many life-threatening conditions, effective non-invasive treatments remain limited. Amylin is a pancreatic and brain-derived peptide ...
Opiate-Induced Plasticity in the Mesolimbic Dopamine System
(State University of New York at Buffalo, 2019)
Substance use disorder is a chronic, relapsing disease that results from cellular maladaptations within discrete regions of the mesolimbic dopamine system, or the ‘reward pathway.’ Two critical regions that are known to ...
Voltage-Gated Calcium Channels Function in Reactive Astrocytes
(State University of New York at Buffalo, 2019)
Astrocytes exhibit excitability in the form of intracellular Ca++ oscillations which are critical for the regulation of many cellular events (Cornell Bell et al., 1990). We previously reported that voltage-gated Ca++ ...
Characterization of novel alpha2/alpha3 subtype-selective GABAA receptor positive allosteric modulators
(State University of New York at Buffalo, 2019)
Millions of individuals endure persistent pain. In the United States alone, about 30% of the population is estimated to suffer from chronic pain. In addition to the physical and emotional burden that chronic pain imparts, ...
Investigating the phenotype of amylin receptor-expressing cells in the ventral tegmental area
(State University of New York at Buffalo, 2019)
The role of amylin in regulating energy balance through its ability to suppress food intake by increasing satiation makes it a promising therapeutic method for obesity. Calcitonin receptor (CTR) is the core component of ...
Magnetothermal Neuromodulation
(State University of New York at Buffalo, 2019)
To understand the phenotypical and aberrant aspects of brain functions, circuital elements within the brain need to be perturbed and the effects correlated. However, the fast dynamics and the complex heterogeneity of neural ...
Dynamic Cerebral Blood Flow Velocity Assessment during Head Down Tilt in Sports-Related Concussions
(State University of New York at Buffalo, 2019)
AbstractIntroduction: Sport-related concussions affect between 1.6 and 3.8 million people in the United States per year (Langlois et al., 2006). Approximately 5% to 10% of children and adolescents will experience a ...
SYNAPTIC TUNING FOR ENHANCED DYNAMIC SENSITIVITY AT PHOTORECEPTOR TERMINALS
(State University of New York at Buffalo, 2019)
Studies of the aspartate-isolated a-wave response from the all-rod retina of the skate, Raja erinacea, have demonstrated that its incremental sensitivity remains Weber-Fechner-like as the intensity of steady background ...
Aberrant immune states of the inner ear resultant of aging and lower level noise
(State University of New York at Buffalo, 2018)
Cochlear immunity is an important process for cochlear homeostasis and diseases. Over the past twenty years, numerous researchers have investigated cochlear immunity as it pertains to inner ear stresses. However, the vast ...