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Behaviors Disrupted due to Over-Expression of Tau in the Cholinergic Pedunculopontine Tegmentum
(State University of New York at Buffalo, 2018)
The pedunculopontine tegmentum (PPTg) is a structure located in the brainstem and has become a main focus of study for neurodegenerative diseases, such as Progressive Supranuclear Palsy (PSP). The PPTg is comprised of ...
Discovery and Pharmacological Characterization of Environmental Melatonin Receptor Modulators
(State University of New York at Buffalo, 2019)
Melatonin targets MT1 and MT2 melatonin receptors that are expressed in brain and peripheral tissues in order to signal “time-of-day” messages for the synchronization of circadian rhythms. In 2017, Popovska-Gorevski et al. ...
Egr3, in the Prefrontal Cortex, Mediates Oxycodone-Induced Pain Relief
(State University of New York at Buffalo, 2019)
Chronic pain is a debilitating and distressing condition with implications extending beyond the physical state of pain like anxiety, depression and cognitive appraisal. Chronic pain can cause neurobiological adaptations ...
Understanding the Scaffolding Mechanisms of Ion Channels by Magi Proteins
(State University of New York at Buffalo, 2019)
Ion channels play important neuromodulatory functions in neurons of the PNS and CNS. In this study, we are focusing on two important ion channels of the nervous system. The first being Slick (KCNT2), a sodium-activated ...
Estrogen Receptor Beta and p53 Signaling Crosstalk in Triple Negative Breast Cancer
(State University of New York at Buffalo, 2018)
Estrogen receptor has long been the most effective diagnostic and prognostic tool in the management of breast cancer. For ER-positive breast cancers, this means better prognosis, more available treatment options, lower ...
Examining the role of E3 Ubiquitin ligase Smurf1 during withdrawal following cocaine self-administration
(State University of New York at Buffalo, 2018)
Drug addiction is a disease characterized by episodes of relapse despite periods of drug abstinence. The ubiquitin-proteasome system (UPS) degrades proteins and is involved in cocaine-induced plasticity in the nucleus ...
Effects of Trace Amine-Associated Receptor 1 Partial Agonist RO5263397 on Morphine-Related Behaviors
(State University of New York at Buffalo, 2018)
A novel G-protein coupled receptor, trace amine-associated receptor 1 (TAAR1), has been identified as an important modulator of the dopaminergic system. As such, TAAR1 has been shown to have a critical role in regulating ...
Novel Anti-Cancer Agents Targeting Epidermal Growth Factor (EGF) protein-protein Interactions
(State University of New York at Buffalo, 2019)
Epidermal growth factor (EGF) mediates several cellular functions and processes such as survival, motility, differentiation, proliferation and death. When it is released by epidermal tissues, EGF binds to cell surface ...
Hsp60 Promotes Aggressive Prostate Cancer by Modulating Mitochondrial Function
(State University of New York at Buffalo, 2019)
Prostate cancer is the second most diagnosed cancer in American men and the third leading cause of cancer-related death in American men. Although the five-year survival rate for patients with androgen-sensitive prostate ...
The Effect of ChemicalX in Reducing Cisplatin-Induced Toxicities, Particularly Nephrotoxicity
(State University of New York at Buffalo, 2018)
Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its dose is limited by severe side effects ...