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Voltage-Gated Calcium Channels Function in Reactive Astrocytes
(State University of New York at Buffalo, 2019)
Astrocytes exhibit excitability in the form of intracellular Ca++ oscillations which are critical for the regulation of many cellular events (Cornell Bell et al., 1990). We previously reported that voltage-gated Ca++ ...
Effects of Trace Amine-Associated Receptor 1 Partial Agonist RO5263397 on Morphine-Related Behaviors
(State University of New York at Buffalo, 2018)
A novel G-protein coupled receptor, trace amine-associated receptor 1 (TAAR1), has been identified as an important modulator of the dopaminergic system. As such, TAAR1 has been shown to have a critical role in regulating ...
Discovery and Pharmacological Characterization of Environmental Melatonin Receptor Modulators
(State University of New York at Buffalo, 2019)
Melatonin targets MT1 and MT2 melatonin receptors that are expressed in brain and peripheral tissues in order to signal “time-of-day” messages for the synchronization of circadian rhythms. In 2017, Popovska-Gorevski et al. ...
Egr3, in the Prefrontal Cortex, Mediates Oxycodone-Induced Pain Relief
(State University of New York at Buffalo, 2019)
Chronic pain is a debilitating and distressing condition with implications extending beyond the physical state of pain like anxiety, depression and cognitive appraisal. Chronic pain can cause neurobiological adaptations ...
Understanding the Scaffolding Mechanisms of Ion Channels by Magi Proteins
(State University of New York at Buffalo, 2019)
Ion channels play important neuromodulatory functions in neurons of the PNS and CNS. In this study, we are focusing on two important ion channels of the nervous system. The first being Slick (KCNT2), a sodium-activated ...
Novel Anti-Cancer Agents Targeting Epidermal Growth Factor (EGF) protein-protein Interactions
(State University of New York at Buffalo, 2019)
Epidermal growth factor (EGF) mediates several cellular functions and processes such as survival, motility, differentiation, proliferation and death. When it is released by epidermal tissues, EGF binds to cell surface ...
Pharmacokinetics and Receptor-Mediated Pharmacodynamics of Methylprednisolone
(State University of New York at Buffalo, 2019)
The corticosteroids possess substantial anti-inflammatory and immunomodulatory activity. Prolonged use of these drugs are, however, associated with adrenal suppression and other dose-limiting metabolic toxicities, manifested ...
Optimization of a Rhodopsin Targeting Ribozyme Knockdown-Reconstitute Strategy for Autosomal Dominant Retinitis Pigmentosa
(State University of New York at Buffalo, 2019)
Autosomal Dominant Retinitis Pigmentosa (adRP) is a progressive retinal degenerative disease that leads to blindness, with around 400,000 cases worldwide. Mutations in the gene coding for Rhodopsin are responsible for ...
The Role of Ferritin and Transferrin Receptor in Oligodendrocyte Maturation and Myelination
(State University of New York at Buffalo, 2019)
There is a critical relationship between oligodendrocyte (OL) development, myelin production and iron. Iron deficiency leads to hypomyelination both in humans and animal models, and the neurological sequelae of hypomyelination ...
Studies on Biodistribution of CDC-Exosomes and their Immunomodulatory Effects on Macrophages
(State University of New York at Buffalo, 2019)
Myocardial infarctions (MIs) commonly result from coronary artery disease leading to an obstruction of coronary blood flow. This can cause irreversible myocardial necrosis and a reduction in heart function. Cardiosphere-Derived ...