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dc.contributor.advisorBalthasar, Joseph
dc.contributor.authorThomas, Veena
dc.contributor.author0000-0002-5202-6697
dc.date.accessioned2018-06-28T15:31:49Z
dc.date.available2018-06-28T15:31:49Z
dc.date.issued2018
dc.date.submitted2018-05-08 10:33:22
dc.identifier.urihttp://hdl.handle.net/10477/77924
dc.descriptionPh.D.
dc.descriptionThe full text PDF of this dissertation is embargoed at author's request until 2020-06-08.
dc.description.abstractSubstantial inter-individual variability (IIV) in monoclonal antibody (mAb) pharmacokinetics has been reported in the clinic. The sources of variability are not well understood and often not explored. Very few preclinical and clinical studies have attempted to examine the sources of IIV. Preclinical investigations, using appropriate mouse models, may allow detailed, mechanistic investigation of possible sources of IIV. The overall objective of this dissertation is to examine putative mechanistic determinants of mAb disposition, identify the sources of variability, elucidate the possible physiological mechanisms involved, and quantify their influence on mAb disposition.
dc.formatapplication/pdf
dc.language.isoen
dc.publisherState University of New York at Buffalo
dc.rightsUsers of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
dc.subjectPharmaceutical sciences
dc.titleInvestigation of Inter-Individual Variability in Monoclonal Antibody Dispositionen_US
dc.typeDissertation
dc.typeText
dc.rights.holderCopyright retained by author.
dc.contributor.departmentPharmaceutical Sciences


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