The Effects of ALAD Genotype and Blood Lead Levels on Anthropometric Measures in a Cohort of Mexican Children
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Objectives: Lead exposure has been shown to affect children’s growth, but this relationship may depend on the presence of susceptibility factors, including genetic variation. Blood lead levels (BLL) differ between groups with different variants of the ALAD gene, which encodes the enzyme aminolevulinic acid dehydratase (ALAD) that participates in heme synthesis. We investigated the association between BLL growth over 12-months in a cohort of Mexican first-graders. We also tested for effect modification of this relationship by ALAD genotype.