Physicomechanical Response of Ionic Polyurethanes on Endothelial Cells
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Segmental polyurethanes (PUs) are well-characterized elastomeric biomaterials that are used in vascular graft applications. PU properties can be engineered by tuning their segmental composition and by regulating inter-segmental interactions. We aim to use ionic PUs as representative vascular graft material to analyze the response of human endothelial cells and correlate it to cell-matrix interactions. We propose to use polycaprolactone-based ionic PU and design a composite (blend) of cationic and anionic PUs to modulate the physicomechanical properties. PUs are designed with two different diisocyanates, hexamethylene diisocyanate (HDI), which has a linear structure and isophorone diisocyanate (IPDI), with a non-linear structure. By utilizing the inter-segmental interaction along with ionic interactions, the relaxation of PU chains can lead to well-defined physicomechanical responses, specifically, viscoelasticity and surface property. Using this system, we aim to underline the interaction between endothelial cells and PUs. The cellular response of HUVECs on the designed PUs will provide understanding of cell-matrix interactions, which can be employed to develop cellularized graft for vascular applications.