The Roles of WT1 and BASP1 in the Development and Maintenance of the Posterior Taste Field
MetadataShow full item record
Taste is one of the fundamental senses that organisms have evolved, which is critical for survival. Taste receptor cells have the function to detect chemicals in the oral cavity and transmit the chemical information to the brain. Those taste receptor cells are housed in taste buds. Within each taste bud, there are type I, type II, type III and basal cells, which have different morphological structures and different cellular functions. In mammals, taste buds are located in 3 distinct sets of specialized taste papillae within the oral cavity, including circumvallate papillae, foliate papillae and fungiform papillae. As those cells are in contact with the external environment and easy to damage, they keep turning over throughout an organism’s life. However, either aging or disease can cause loss of taste. Despite the importance of taste to our life, currently very little is known about the development and maintenance of the taste system.