Further Development and Application of an LC/MS Analysis of Plasma Oxysterol
Bhattacharya, Sonia Bholanath
MetadataShow full item record
Importance: Oxysterols are biologically active derivatives of cholesterol of recent interest that encompass roles in signaling, regulation, immunity and disease biomarker amongst others. We examined the liquid chromatography-mass spectrometry (LC-MS) analysis of 6 clinically relevant oxysterols in order to improve the quantitation, chromatographic resolution and assay throughput. We also explore the use oxysterols as biomarkers in diagnosing and delineating clinical phenotypes of multiple sclerosis.