The Effect of Skewed Elevation in dNTP pools on Loss of Heterozygosity in Saccharomyces cerevisiae
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DNA precursors, deoxyribonucleotide triphosphates (dNTP), are the basic components of DNA. Enzyme ribonucleotide reductase (RNR) tightly regulates the levels of dNTP pools to ensure high fidelity DNA replication and repair. Misregulated levels of dNTP pools cause mutagenesis which impacts genome stability and cellular fitness; characteristics of cancer cells. Even though, a basic causal relationship between elevated dNTP pools and genomic instability has been established, some of the underlying mechanisms remain poorly understood.