ASSESSMENT OF VARIABLE-DOSE SCHEDULING EFFECTS ON THE KINETICS AND HOMING OF ANTIGEN-SPECIFIC T CELLS IN CANCER VIA OPTICAL IMAGING
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Ovarian Epithelial cancer is the most prevalent form of ovarian cancer overall. It is the leading cause of gynecologic cancer mortality, partly due to its lack of distinctive symptoms. The mainstay for treatment for metastatic ovarian cancer has largely been chemotherapeutics, but recently immunotherapy has surfaced as a potential treatment. The initial results of immunotherapy are promising, with demonstration of low rates of off-target effects and high specificity towards tumors. Nevertheless, there are various hurdles to overcome before immunotherapy becomes a routine and efficacious form of treatment. Preclinical models are valuable for basic studies of adoptive T cell therapies. We propose that molecular imaging can be used to better understand T cell therapies. Molecular imaging is field which employs highly sensitive imaging to image cells noninvasively and quantitatively. Combining molecular imaging with adoptive T cell therapy can enhance our understanding of T cell therapies by helping assess T cell kinetics and trafficking during tumor killing.