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dc.contributor.advisorParashurama, Natesh
dc.contributor.authorYarovoy, Iven
dc.date.accessioned2018-06-28T20:34:17Z
dc.date.available2018-06-28T20:34:17Z
dc.date.issued2018
dc.date.submitted2018-05-18 09:21:22
dc.identifier.urihttp://hdl.handle.net/10477/78112
dc.descriptionM.S.
dc.description.abstractOvarian Epithelial cancer is the most prevalent form of ovarian cancer overall. It is the leading cause of gynecologic cancer mortality, partly due to its lack of distinctive symptoms. The mainstay for treatment for metastatic ovarian cancer has largely been chemotherapeutics, but recently immunotherapy has surfaced as a potential treatment. The initial results of immunotherapy are promising, with demonstration of low rates of off-target effects and high specificity towards tumors. Nevertheless, there are various hurdles to overcome before immunotherapy becomes a routine and efficacious form of treatment. Preclinical models are valuable for basic studies of adoptive T cell therapies. We propose that molecular imaging can be used to better understand T cell therapies. Molecular imaging is field which employs highly sensitive imaging to image cells noninvasively and quantitatively. Combining molecular imaging with adoptive T cell therapy can enhance our understanding of T cell therapies by helping assess T cell kinetics and trafficking during tumor killing.
dc.formatapplication/pdf
dc.language.isoen
dc.publisherState University of New York at Buffalo
dc.rightsUsers of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
dc.subjectBiomedical engineering
dc.subjectChemical engineering
dc.subjectCellular biology
dc.titleASSESSMENT OF VARIABLE-DOSE SCHEDULING EFFECTS ON THE KINETICS AND HOMING OF ANTIGEN-SPECIFIC T CELLS IN CANCER VIA OPTICAL IMAGING
dc.typeThesis
dc.typeText
dc.rights.holderCopyright retained by author.
dc.contributor.departmentChemical and Biological Engineering


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