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dc.contributor.advisorAga, Diana
dc.contributor.authorMullen, Rachel
dc.date.accessioned2018-06-28T20:34:24Z
dc.date.available2018-06-28T20:34:24Z
dc.date.issued2018
dc.date.submitted2018-05-18 11:38:25
dc.identifier.urihttp://hdl.handle.net/10477/78124
dc.descriptionPh.D.
dc.description.abstractAs pharmaceutical usage is increasing, they are becoming increasingly ubiquitous in the environment. The synergistic effects associated with chronic exposure is still being realized, but certain pharmaceutical classes are closely associated with increase of antibiotic resistant genes (ARGs) and adverse psychological effects in aquatic organisms. Consequently, it is critical to understand the levels being released as a result of current practices and to be proactive in anticipating and investigating new routes of exposure. The research presented here investigates pharmaceutical fate from both regulatory and exploratory sources, including conventional full-scale and advanced pilot-scale wastewater treatment processes, and common and novel fertilizing techniques by liquid chromatography tandem mass spectrometry (LC-MS/MS). Sample extraction and instrument methods were developed, optimized, and validated. Conventional and advanced wastewater treatment plant (WWTP) stages across 5 WWTPs were investigated for removal efficiency of pharmaceuticals, and a deeper look was taken at an advanced ozonation WWTP process in order to identify transformation products of antidepressants. Next, the fate of pharmaceuticals in human urine when it was processed and applied as an agricultural fertilizer was investigated. Lastly, young maize plants were grown in manure-amended soil and plant uptake and occurrence of ARGs was explored.
dc.formatapplication/pdf
dc.language.isoen
dc.publisherState University of New York at Buffalo
dc.rightsUsers of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
dc.subjectChemistry
dc.subjectAnalytical chemistry
dc.titleTRACING PHARMACEUTICALS FROM URINE THROUGH WASTEWATER TREATMENT PLANTS AND ASSESSMENT OF THEIR POTENTIAL TRANSFER TO EDIBLE CROPS
dc.typeDissertation
dc.rights.holderCopyright retained by author.


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