An Examination of Fluconazole and Prevention of Systemic Fungal Infection in Lymphoma A Retrospective Chart Review
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Objective: To determine if fluconazole is still effective in preventing fungal infections. Theoretical Framework: The RE-AIM framework was selected to guide this quality improvement project. Project Methods: A retrospective chart review of 100 charts were reviewed to determine if patients who received prophylactic fluconazole subsequently acquired invasive fungal infections. Data related to age, serum absolute neutrophil count, and serum albumin levels were planned but only descriptive statistics were used to describe the sample. All of the patients in the sample had active lymphoma diagnoses and were on chemotherapeutic treatment regimens. Data Analysis: Descriptive statistics including frequency and percentages were used to summarize the data collected related to the sample characteristics of age, type of lymphoma, and neutrophil counts. Results: Of the 74 charts reviewed there was no patients with positive cultures for an invasive fungal infection, which negated the need for the planned chi-square analysis. Descriptive statistics did not show major differences in demographics Conclusion: Findings do not prove that fluconazole is the primary reason for the lack of fungal infection. The lack of neutropenia among the sample may be the true reason for lack of fungal infection. Serum albumin levels, or age group also do not have an effect on presence of invasive fungal infection. Patients in this sample were not at a high enough risk for invasive fungal infection based on their acceptable neutrophil counts, which suggests that similar patients can still be used for prophylactic purposes.