Novel Ciprofloxacin-based Polymer-Antibiotic Conjugates as Antibacterial Additive in Dental Resin
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As the most typical and widely affecting dental health issue, dental caries becomes the number one topic of our dental health, and innovative ideas are needed to develop new treatment approaches for overcoming the shortcomings of existing ones. A whole new idea on the modification of the restorative resins currently used for caries treatment was first hypothesized by employing polymer-drug conjugate (PDC), more specifically polymer-antibiotic conjugate (PAC), which makes the resin not only a filling material but an antibiotic delivery system which, in principle, could ensure antimicrobial effectiveness for a much longer time period as compared with directly using small-molecular antibiotics as additives. Moreover, the polymer backbone of PAC will be constructed using a commonly used monomer in the dental resin, i.e. 2-hydroxyethyl methacrylate (HEMA), to promote compatibility between the resin and the PAC during the mixing and further curing process. Thus this thesis aims to provide a general strategy for the synthesis of these PACs and PAC-added dental resins, and to demonstrate physical properties and antimicrobial performances of these new resins using the blank resin and the antibiotic as controls, respectively. In this proof-of-concept study, ciprofloxacin was selected as the antibiotic because it is very commonly used and has multiple functional group for modification. The preparation and characterization of ciprofloxacin-based monomer-antibiotic-conjugate and the corresponding PACs will be addressed in this thesis. The property and antimicrobial performance against Streptococcus mutans of the PAC-added dental resins will be discussed after the preparation of these new resins is presented.