Developing High Throughput Screening Methods for Co-crystal Photoactivity
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Co-crystals are a subclass of crystals that are comprised of two or more different molecular components. A major theme in co-crystal research is that co-crystals display different properties than the components that comprise them. Of the many uses for co-crystals, some of the more popular uses extend into pharmaceutical and energetic materials research where active pharmaceutical ingredients, or APIs, are co-crystallized with coformers to improve bioavailability and solubility. Mechanochemistry has emerged as a key tool in the synthesis and engineering of co-crystals due to how quickly co-crystals can be generated when compared to growing crystals using slow evaporation. Among the several mechanochemical methods used for co-crystal production such as ball-milling and grinding, liquid-assisted sonication offers a quick and easy method for the formation of co-crystals with the added benefit of being able to be performed at the milligram scale which decreases the amount of material needed for these experiments. Powder x-ray diffraction, or PXRD, is how the formation of a co-crystal can be analyzed by comparing the powder patterns of each component and the mixture. If the mixture is unique to both components, then there exists the likelihood that a co-crystal had formed. The presence of a co-crystal cannot be confirmed using this method, but it can narrow down choices for growing single crystals which leads to a single crystal structure that will confirm a co-crystal.In this work, we are interested in forming co-crystals of photochromic ruthenium sulfoxide complexes that undergo a linkage isomerization from the S-bonded form to the O-bonded form when irradiated. Utilizing high-throughput liquid-assisted sonication, potential co-crystals are found which will lead to the ultimate goal of single crystals of the co-crystals for time resolved x-ray studies.