Understanding the Effects of Engineered Nanomaterials on Mammalian Cells and Plants Using a Mass Spectrometry Based Approaches
Chavez Soria, Nita
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Nanotechnology focuses on the development and application of materials in the nanoscale range. Engineered nanomaterials (ENMs) are usually defined as particles of 1-100 nm in size in at least one dimension, which have been developed for specific applications. New ENMs have allowed for applications in agriculture, environmental remediation, medicine, and production of consumer goods. However, the adverse effects to humans, animals and the environment remain largely unknown. Due to the complex nature of ENMs, there is no single analytical characterization technique or toxicity protocol available to help understand the fate and adverse effects of ENMs. Thus, in this dissertation, a metabolomics approach was applied to gain a deeper understanding on the effects of ENMs in different biological organisms at the metabolome level, to determine the uptake mechanism of nanoparticles (NPs) as well as identify potential biomarkers of exposure.