2019-09-01 UB Theses and Dissertations (public)
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Deciphering BK Channel Function in Human Oligodendrocyte Progenitor Cells
(State University of New York at Buffalo, 2019)Demyelination in neurodegenerative disorders, is characterized by chronic destruction of myelin leading to attenuated saltatory conduction and ultimately axonal dystrophy. Remyelination, the regeneration of lost myelin, ... -
Mechanism and Application of Rapid Stereolithography 3D Printing for Engineered Tissue Models
(State University of New York at Buffalo, 2019)3D bioprinting is an emerging technology for tissue fabrication; however, its application in large tissue fabrication is limited due to difficulty to fabricate at multiple length scales and the slow printing speed resulting ... -
Discovery and Pharmacological Characterization of Environmental Melatonin Receptor Modulators
(State University of New York at Buffalo, 2019)Melatonin targets MT1 and MT2 melatonin receptors that are expressed in brain and peripheral tissues in order to signal “time-of-day” messages for the synchronization of circadian rhythms. In 2017, Popovska-Gorevski et al. ... -
In-Vivo Efficacy of Environmental Chemical & Novel Type Preferring Ligands at SCN Melatonin Receptors in Models of Chronobiological Behaviors
(State University of New York at Buffalo, 2019)The goal of the present research was to investigate efficacy of environmental chemical and novel type preferring melatonin receptor ligands utilizing in-vivo rodent models of chronobiological behaviors. Environmental ... -
Egr3, in the Prefrontal Cortex, Mediates Oxycodone-Induced Pain Relief
(State University of New York at Buffalo, 2019)Chronic pain is a debilitating and distressing condition with implications extending beyond the physical state of pain like anxiety, depression and cognitive appraisal. Chronic pain can cause neurobiological adaptations ... -
Lesbian and Gay Life in the Queen City and Beyond: Resistance, Space, and Community Mobilization in the Southwest Missouri Ozarks
(State University of New York at Buffalo, 2019)Lesbian and gay life in southwest Missouri in the second half of the twentieth century was largely characterized by coalition building, the creation of shared identities, and the development of a myriad of tactics for ... -
Iron Metabolism in Oligodendrocytes: The Role of Ferritin and Ceruloplasmin
(State University of New York at Buffalo, 2019)Iron deficiency leads to hypomyelination both in humans and animal models, and the neurological sequelae of hypomyelination are significant. Therefore, understanding mechanisms of iron import into oligodendrocytes is ... -
Optimization of a Rhodopsin Targeting Ribozyme Knockdown-Reconstitute Strategy for Autosomal Dominant Retinitis Pigmentosa
(State University of New York at Buffalo, 2019)Autosomal Dominant Retinitis Pigmentosa (adRP) is a progressive retinal degenerative disease that leads to blindness, with around 400,000 cases worldwide. Mutations in the gene coding for Rhodopsin are responsible for ... -
An Investigation of the Relationship Between Structural Disruption and Functional Connectivity in Multiple Sclerosis and its Effect on Cognition
(State University of New York at Buffalo, 2019)Although previous research has established a link between structural damage and functional reorganization in Multiple Sclerosis, it remains unclear what mediates this link and how it affects people with MS. Using neuroimaging ... -
Vascular Tissue Engineering: Harnessing the Body's Regenerative Potential
(State University of New York at Buffalo, 2019)Cardiovascular disease is the leading cause of death world-wide, with an estimated 17.9 million deaths in 2016. Therefore, the need for vascular tissue is at the forefront of tissue engineering endeavors. In this dissertation ... -
Synthesis and Self-Assembly of Amphiphilic Bottlebrush Copolymers
(State University of New York at Buffalo, 2019)Polymeric materials with nanosized channels can serve as versatile platforms for a variety of applications. Self-assembly of block copolymers into nanostructured morphologies and subsequent removal one of the components ... -
Climate Change Adaptation in Coastal Cities of Developing Countries: An Examination of Municipal Climate Action Plans
(State University of New York at Buffalo, 2019)Adaptation planning is crucial for cities and their communities to plan for and take actions to tackle climate change, the current greatest risk to human-being and ecosystem. Cities across many regions have benefited from ... -
Recent Developments in Statistical Methods of Partially Paired Data
(State University of New York at Buffalo, 2020)Paired data are ubiquitous in practice, such as in pre-post treatment studies, or in genomic experiments to find differentially expressed genes between two conditions. However, missing values often occur in practice. The ... -
Essential Role of CD27/CD70 pathway in inflammatory T cell response
(State University of New York at Buffalo, 2019)Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for a variety of hematologic and immunologic diseases. However, graft-versus-host disease (GVHD) remains the major complication ... -
CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival
(State University of New York at Buffalo, 2019)Sustained humoral immunity depends on the survival of bone marrow (BM) resident long-lived plasma cells (LLPC). However, the mechanisms governing LLCP survival are not completely understood. We have previously shown that ... -
Evaluation of cohesive soil erosion parameters
(State University of New York at Buffalo, 2019)Assessment of cohesive soil erosion is of paramount importance in various areas of science and engineering. For example, soil erosion can cause increased pollution in water bodies and scour around bridge piers, which is ... -
Recent Developments in Biomarker Evaluation with Applications in Lung and Ovarian Cancer
(State University of New York at Buffalo, 2019)In the field of diagnostic studies, ROC curve and related summary measures are commonlyused for the purpose of biomarker evaluation under binary classification. In practice,many disease processes naturally involve more ... -
Thin Film Composite Membranes Comprising Amorphous Poly(ethylene oxide) for Carbon Capture
(State University of New York at Buffalo, 2020)Poly(ethylene oxide) (PEO) based polymers are the leading materials for membrane CO2 capture from coal-fired power plant flue gas because CO2 can interact favorably with ether oxygen, leading to high CO2 permeability and ... -
Learning to Build Multimodal Intelligence across Vision, Language and Speech
(State University of New York at Buffalo, 2019)Artificial intelligence can already do many things that humans cannot. But how far away are we from building ``human-like" AI? What are the key problems that we need to solve before we get there?Human gain and evolve ... -
Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels
(State University of New York at Buffalo, 2019)Xerostomia and Sjӧgren’s Syndrome are conditions associated with loss in salivary volume that is needed to regulate the health of the oral cavity. Current therapies are limited to the introduction of artificial saliva and ...
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