Engraftment Syndrome and Mucositis in Autologous Transplant
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Mucositis and engraftment syndrome are two complications of autologous stem cell transplant. Mucositis causes pain, decreased oral intake, and increases risk of infection during transplant. Engraftment syndrome is a complication that causes fever, rash, pulmonary infiltrates, diarrhea, vomiting, and hypoxia during transplant which then can lead to more days in the hospital, more days on antibiotics, and increased transfusions needed. Engraftment syndrome can require treatment with steroids and be life-threatening in some cases. The purpose and aim of this project was to look at mucositis and engraftment in syndrome in patients who received a hyperbaric oxygen treatment prior to transplant versus those who did not. Increasing knowledge of engraftment syndrome and mucositis with and without hyperbaric oxygen treatment will improve guidance for prevention and treatment in autologous transplant patients. The theoretical framework for this project is Neuman’s System Model. This project was a retrospective chart review of data collected during the autologous stem cell transplants at the University of Rochester in which some of the patients received an HBO treatment prior to transplant. Statistical analysis of data did not yield significant results but did lead to insights into autologous stem cell transplant patients, HBO, engraftment syndrome, and mucositis. Mucositis and engraftment syndrome in this particular patient population needs additional research in order to improve patient outcomes by preventing complications.