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Now showing items 331-340 of 383
LONG-TERM PSYCHOSOCIAL IMPACT ON POLICE OFFICERS: POST-HURRICANCE KATRINA
(2011-04-18)
DESCRIPTION (provided by applicant): The present proposal seeks to examine the long term post- hurricane Katrina impact on police officers who policed the disaster in St. Bernard Parish, LA, one of the most devastated ...
CLINICAL PHARMACOLOGY QUALITY ASSURANCE AND QUALITY CONTROL
(2011-04-18)
The purpose of this solicitation is to award a contract to develop a Clinical Pharmacology Quality Assurance and Quality Control (PQA/QC) Program that provides a technical and administrative infrastructure to ensure efficient ...
IMAGING ANTIGEN AND ADJUVANT UPTAKE FOR ENHANCING RESPONSE TO MUCOSAL VACCINES
(2011-04-18)
DESCRIPTION (provided by applicant): Because most human infections affect or gain entry through the mucosal surfaces of the oro-gastrointestinal, respiratory, and genitourinary tracts, future vaccines to elicit protection ...
REGULATION OF DNA REPLICATION AND REPAIR
(2011-04-18)
DESCRIPTION (provided by applicant): The long-term goal of this research program is to develop an integrated mechanistic view of how organisms coordinate the actions of their replication machinery with those of other ...
REARRANGMENTS AT THE NMDA RECEPTOR LIGAND BINDING DOMAIN INTERFACE
(2011-04-18)
DESCRIPTION (provided by applicant): Interactions at the ligand binding domain (LBD) dimer interface of ionotropic glutamate receptors (iGluRs) play a pivotal role in receptor activation and desensitization. The current ...
MYOCARDIAL PROPERTIES OF TIMOTHY SYNDROME
(2011-04-18)
DESCRIPTION (provided by applicant): Disturbances in Ca2+ homeostasis have long been linked to arrhythmias. Timothy Syndrome (TS) is the only cell surface Ca2+ channel defect linked to arrhythmia in humans. A single point ...
PHARMACOGENETICS IN INDOLEALKYLAMINE METABOLISM AND DRUG INTERACTIONS
(2011-04-18)
DESCRIPTION (provided by applicant): The overall objective of the proposed work is to delineate the pharmacogenetics of indolealkylamine (IAA) metabolism and drug-drug interactions. IAA xenobiotics represent a major class ...
ALCOHOL CONSEQUENCES AND PREDICTION OF SHORT-TERM CHANGES IN DRINKING BEHAVIOR
(2011-04-18)
DESCRIPTION (provided by applicant): Project Summary/Abstract: Heavy alcohol use and its associated consequences are common during the college years, and are associated with deleterious short- and long-term outcomes for ...
ADOLESCENT ALCOHOL USE, SEXUAL ASSAULT AND STD/HIV RISK
(2011-04-18)
DESCRIPTION (provided by applicant): The Candidate is seeking a Mentored Research Scientist Development Award (MRSDA; K01) in order to develop an independent program of research on adolescent alcohol use, sexual risk ...
ENGINEERING A TRANSMITTER BINDING SITE
(2011-04-18)
DESCRIPTION (provided by applicant): A fundamental principle of biomedicine is that small molecules can bind to specific receptors to trigger physiological responses. We seek to understand the energetic nature of the ...