Recent Submissions

  • REGULATION OF HOST-ADAPTATION OF THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI 

    LI, CHUNHAO Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Lyme disease is the most common vector-borne disease in the United State. The causative agent Borrelia burgdorferi (Bb) is maintained through a complex enzootic cycle involving in tick ...
  • UNDERSTANDING UNIQUE ASPECTS OF MOTILITY AND CHEMOTAXIS IN BORRELIA BURGDORFERI 

    LI, CHUNHAO Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Spirochetes are a medically significant but poorly understood group of bacteria. These organisms cause several important human diseases, such as syphilis, Lyme disease and leptospirosis. ...
  • UNDERSTANDING UNIQUE ASPECTS OF MOTILITY AND CHEMOTAXIS IN BORRELIA BURGDORFERI 

    LI, CHUNHAO Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Spirochetes are a medically significant but poorly understood group of bacteria. These organisms cause several important human diseases, such as syphilis, Lyme disease and leptospirosis. ...
  • BINGE DRINKING IN COUPLES AND INTIMATE PARTNER VIOLENCE 

    LEONARD, KENNETH E Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Although frequent heavy drinking patterns are related to the occurrence of intimate partner violence (IPV) among men, the role of these women's drinking patterns in IPV is poorly ...
  • MESENCHYMAL STEM CELL THERAPEUTICS IN HIBERNATING MYOCARDIUM 

    LEE, TECHUNG Principal Investigator (2011-04-18)
    Chronic myocardial ischemia leading to heart failure is a leading cause of morbidity and mortality in theUnited States. Experimental myocardial stem cell therapeutics have been performed largely in the acuteischemia model. ...
  • ANTENATAL BETAMETHASONE IN LATE PRETERM GESTATION LAMBS 

    LAKSHMINRUSIMHA, SATYANARAYANA Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The incidence of late preterm births (defined as births at 34 0/7 to 36 6/7 wk gestation) have been steadily increasing over the past decade and account for the ~ 75% of all preterm ...
  • SELF-ADMINISTERED CBT FOR IBS: A MULTICENTER TRIAL 

    LACKNER, JEFFREY M Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Irritable bowel syndrome (IBS) is a chronic, prevalent, often disabling, GI disorder for which there is no reliable and satisfactory medical option for its full range of symptoms ...
  • SELF-ADMINISTERED CBT FOR IBS: A MULTICENTER TRIAL 

    LACKNER, JEFFREY M Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Irritable bowel syndrome (IBS) is a chronic, prevalent, often disabling, GI disorder for which there is no reliable and satisfactory medical option for its full range of symptoms ...
  • MANAGING IONIC IRON: MOLECULAR ARCHITECTURE AND MECHANISM OF CELL IRON METABOLISM 

    KOSMAN, DANIEL J. Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The solution and redox properties of iron that make it the metal prosthetic group of choice for the activation of otherwise kinetically inert substrates, including dioxygen, also make ...
  • FERROXIDASE (FET3) AND PERMEASE (FTR1) IN IRON UPTAKE 

    KOSMAN, DANIEL J. Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Multicopper oxidases (MCOs) couple the 4e- reduction of dioxygen to 2H2O with the oxidation of 4 equivalents of a 1-electron donor. A sub-family of these ubiquitous enzymes possesses ...
  • INFLUENZA THERAPY BY AU-NANOROD 5'PPP-NS1-SIRNA/CDNA TARGETING OF BRONCHIAL CELLS 

    KNIGHT, PAUL R Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): This application proposes to develop two novel prophylactic and therapeutic non-viral gene transfer strategies that target pulmonary cells in vivo employing nanotechnology. The lung is ...
  • PATHOGENESIS OF ASPIRATION PNEUMONITIS 

    KNIGHT, PAUL R Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Gastric aspiration is a major risk factor for the development of acute lung injury (ALI) and ARDS. This proposal examines cellular mechanisms that increase the risk of aspiration-associated ...
  • AFFECT AND DECISION-MAKING FOR CANCER-RELATED BEHAVIORS 

    KIVINIEMI, MARC T Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Alleviating cancer mortality depends in part on achieving significant changes in behavior. Doing so requires a solid understanding of how and why individuals choose to engage in particular ...
  • CORTICOSTEROID PHARMACOKINETICS AND PHARMACODYNAMICS 

    JUSKO, WILLIAM J Principal Investigator (2011-04-18)
    No abstract available.
  • MATHEMATICAL MODELS IN PHARMACODYNAMICS 

    JUSKO, WILLIAM J Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The major factors determining drug responses are the input and disposition rates controlling pharmacokinetics, drug distribution to the site of action (biophase), the mechanism of drug ...
  • ROLE OF PROTEIN NITRATION IN CISPLATIN MEDIATED OTOTOXICITY 

    JAMESDANIEL, SAMSON Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Nitration of cochlear proteins indicates oxidative posttranslational modification that can lead to catastrophic consequences, depending upon the functional activity of the nitrated ...
  • ROLE OF NAREXIN IN NEUROMUSCULAR DISEASE 

    ISACKSON, PAUL J Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The proposed study would characterize a newly identified gene, narexin on chr6, which contains domains most similar in sequence to Notch ligands and to agrin. Both of these molecules ...
  • TIME RESOLVED STUDIES OF TRANSPORT IN RENAL EPITHELIAL CELLS 

    HUA, ZONGLU S Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): My educational background is in physics (B. S. and M.S.) and materials engineering (PhD). My academic research over the last five years has been focused on both ballistic electron ...
  • TIME RESOLVED STUDIES OF TRANSPORT IN RENAL EPITHELIAL CELLS 

    HUA, ZONGLU S Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): My educational background is in physics (B. S. and M.S.) and materials engineering (PhD). My academic research over the last five years has been focused on both ballistic electron ...
  • NOISE-INDUCED ACUTE HAIR CELL DEATH 

    HU, BO HUA Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The plasma membrane of the cell plays an essential role in the maintenance of cellular homeostasis. It is also the first site in transferring a mechanical force into the hair cell. While ...

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