Now showing items 1-20 of 229

  • AUDITORY CORTEX PLASTICITY AND TINNITUS 

    ALLMAN, BRIAN Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Tinnitus, a subjective perception of a phantom auditory sensation (e.g., ringing in the ears), affects approximately 10-15% of the general population. At present, there is no cure, and ...
  • STEM CELLS FOR VASCULAR TISSUE ENGINEERING 

    ANDREADIS, STELIOS THEOHARIS Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Due to rise in cardiovascular disease throughout the world, there is increasing demand for small diameter blood vessels as replacement grafts. Although venous grafts are currently the ...
  • MULTIPLE ACTIVITY PATTERNS OF ACETYLCHOLINE RECEPTORS 

    AUERBACH, ANTHONY L Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The muscle acetylcholine receptor (AChR) is an ion channel that mediates transmission at the nerve-muscle synapse. After binding two transmitter molecules, the AChR switches rapidly ...
  • ENGINEERING A TRANSMITTER BINDING SITE 

    AUERBACH, ANTHONY L Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): A fundamental principle of biomedicine is that small molecules can bind to specific receptors to trigger physiological responses. We seek to understand the energetic nature of the ...
  • REGULATION OF INTRINSIC ACTIVITY OF THE EPITHELIAL NA+ CHANNEL 

    AWAYDA, MOUHAMED S. Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The Epithelial Na+ Channel or ENaC is rate limiting to sodium absorption in renal epithelia. Channel activity sets the final urinary sodium concentration and determines in part sodium ...
  • DOPAMINE NEUROTRANSMISSION IN ADHD 

    BADGAIYAN, RAJENDRA D Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): In this second resubmission we have addressed the concerns and comments of reviewers. The proposal now includes two additional experiments designed to measure the tonic pool of dopamine ...
  • EFFECT OF SS-ASSOCIATED CYTOKINES ON SALIVARY GLAND DYSFUNCTION 

    BAKER, OLGA JULIANA Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Sjogren's syndrome (SS) is an autoimmune disorder characterized by inflammation and dysfunction of salivary glands, resulting in impaired secretory function. Levels of the pro-inflammatory ...
  • PHARMACOKINETIC STRATEGIES TO OPTIMIZE IP CHEMOTHERAPY 

    BALTHASAR, JOSEPH P Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Ovarian cancer is the leading cause of gynecologic cancer death in the United States, and there is substantial need for the development of improved strategies to treat this disease. The ...
  • PHARMACOLOGY AND BIOENGINEERING OF NEW TREATMENT OF ITP 

    BALTHASAR, JOSEPH P Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Immune thrombocytopenic purpura (ITP) is a common autoimmune disease that is associated with ~50,000 new cases each year in the United States. Approximately 25-30% of chronic ITP patients ...
  • DEVELOPING INHIBITORS OF LUXS-DEPENDENT QUORUM SENSING SYSTEMS IN ORAL BACTERIA 

    LI, CHUNHAO Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Quorum sensing is a type of bacterial cell-to-cell communication, and it is achieved through the production, release and detection of small signaling molecules called autoinducers (AIs). ...
  • ROLE OF ZONULA OCCLUDENS TOXIN IN THE PATHOGENESIS OF TREPONEMA DENTICOLA 

    LI, CHUNHAO Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Periodontal diseases are a group of infections that affect the structures surrounding teeth, mainly including gingivitis and periodontitis. The most common form of periodontal diseases ...
  • DEVELOPMENT AND APPLICATIONS OF PHOTOINDUCIBLE BIOORTHOGONAL CHEMISTRY 

    LIN, QING Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Development and Applications of Photoinducible Bioorthogonal Chemistry ABSTRACT Bioorthogonal chemistry has emerged as a powerful tool in probing biomolecular structure and function in ...
  • SALIVARY MUC7 ANTIMICROBIAL PEPTIDE:RIM101 RESPONSE AND MECHANISM OF ACTION. 

    LIS, MACIEJ MIROSLAW Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Cationic antimicrobial peptides (CAMP), 12-50 residues long eptides with high content of cationic amino acids, are characterized by strong activities directed against broad range of ...
  • ADOLESCENT ALCOHOL USE, SEXUAL ASSAULT AND STD/HIV RISK 

    LIVINGSTON, JENNIFER A Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The Candidate is seeking a Mentored Research Scientist Development Award (MRSDA; K01) in order to develop an independent program of research on adolescent alcohol use, sexual risk ...
  • EFFECT OF SELECTIVE INNER HAIR CELL LOSS ON FUNCTIONAL HEARING 

    LOBARINAS, EDWARD Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Although outer hair cells (OHC) play a major role in amplifying mechanical energy in the inner ear, it is the inner hair cells (IHC), which contact 90-95% of the auditory afferent fibers ...
  • INNOVATIVE NANOTHERAPY FOR DRUG ADDICTION. 

    MAHAJAN, SUPRIYA DINKAR Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): The dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is critical to the pathogenesis of drug addiction by modulating both transcriptional and post-translational events ...
  • EFFECTS OF ETHANOL EXPOSURE DURING INVOLUTION ON POST-PARTUM BREAST CANCER" 

    MASSO-WELCH, PATRICIA ANN Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Susceptibility of the breast to carcinogenesis is influenced by the developmentally dynamic state of the mammary microenvironment during the time of exposure to carcinogenic insult. For ...
  • EFFECTS OF ETHANOL EXPOSURE DURING INVOLUTION ON POST-PARTUM BREAST CANCER" 

    MASSO-WELCH, PATRICIA ANN Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Susceptibility of the breast to carcinogenesis is influenced by the developmentally dynamic state of the mammary microenvironment during the time of exposure to carcinogenic insult. For ...
  • MYOSIN HEAVY CHAIN POLYMORPHISM IN HYBRID MUSCLE FIBERS 

    MEDLER, SCOTT A Principal Investigator (2011-04-18)
    DESCRIPTION (provided by applicant): Skeletal muscles are highly plastic tissues, continually responding to a variety of imposed demands. This plasticity arises from the ability of individual muscle fibers to change size ...
  • DEVELOPMENT AND PHARMACOLOGY OF NOVEL LIPIDIC RAHF 

    BALU-IYER, SATHY VENKAT Principal Investigator (2011-04-18)
    Advances in protein engineering have led to the development of proteins as therapeutic agents. However, acommon complication is the reduction of efficacy due to antibody response. Factors that influence antibodyresponse ...